Role of interleukin 18 in rheumatoid arthritis.
نویسندگان
چکیده
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منابع مشابه
Role of Interleukin-37 in Inflammatory and Autoimmune Diseases
Interleukin-1 family 7 (IL-1F7) is a novel member of IL-1F cytokines. IL-1F7 is more commonly known as IL-37. IL-37 join the α-subunit of the IL-18 receptor, or IL-18 binding protein (IL-18BP), and binding of these proteins can enhance the IL-18 suppression. IL-37 also translocates to the cell nucleus and affects gene transcription. IL-37 inhibits the phosphorylation of p38 mitogen-activated pr...
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Introduction Rheumatoid arthritis is the most common inflammatory disease of the joints and in addition to physical disability, mental disorders are very common in these patients. mental rumination is one of the problems that patients with rheumatoid arthritis face, and one of the factors that has a great impact on it is the perception of pain and functional dysfunction of patients. Therefore,...
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Interleukin 18 (IL-18), a member of the IL-1 superfamily of cytokines has been demonstrated to be an important mediator of both innate and adaptive immune responses. Several reports have implicated its role in the pathogenesis of rheumatoid arthritis (RA). Although biologic therapy is firmly established in the treatment of a number of inflammatory diseases including RA, partial and non-responde...
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عنوان ژورنال:
- Annals of the rheumatic diseases
دوره 62 Suppl 2 شماره
صفحات -
تاریخ انتشار 2003